|
KMID : 0665220170300030510
|
|
Korean Journal of Food and Nutrition
2017 Volume.30 No. 3 p.510 ~ p.514
|
|
|
Effect of Plantago asiatica L. Water Extracts on Mice Spleen and Cytokine Cells Activation
|
|
Ryu Hye-Sook
|
|
|
Abstract
|
|
|
|
Plantago asiatica L., observed frequently in East Asia, is a known herb used in traditional medical remedies several studies report that P. asiatica L has anti-inflammatory and antioxidant effects. To determine the production of cytokines (IL-2, IFN-γ, and TNF-α) induced by lipopolysaccharide (LPS) and non-LPS-stimulated macrophages, an ELISA assay was conducted using cytokine kits. Mice splenocytes were cultured for 48 h with various concentrations of P. asiatica L. (5, 10, 50, 100, 250, 500, and 1,000 μg/mL) or with mitogens (ConA or LPS). P. asiatica L. increased the proliferation of mice splenocytes, especially under the condition of its concentration ranging from 250 to 1,000 μg/mL. In addition, Plantago asiatica L. notably induced cytokine production of (IL-2, IFN-γ, and TNF-α) at its concentration of 250~500 μg/mL. These results suggest that supplementation with P. asiatica L. water extracts may play a potential role in enhancing immune function by mediating splenocyte proliferation and cytokine production through its anti-inflammatory activit.
|
|
|
KEYWORD
|
|
|
splenocytes proliferation, Plantago asiatica L., cytokine IL-2 IFN-γ, TNF-α, immune
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|